A closed-loop anesthetic delivery system for real-time control of burst suppression

A closed-loop anesthetic delivery system for real-time control of burst suppression.

OBJECTIVE There is growing interest in using closed-loop anesthetic delivery (CLAD) systems to automate control of brain states (sedation, unconsciousness and antinociception) in patients receiving anesthesia care. The accuracy and reliability of these systems can be improved by using as control signals electroencephalogram (EEG) markers for which the neurophysiological links to the anesthetic-...

Real-time closed-loop control in a rodent model of medically induced coma using burst suppression.

BACKGROUND A medically induced coma is an anesthetic state of profound brain inactivation created to treat status epilepticus and to provide cerebral protection after traumatic brain injuries. The authors hypothesized that a closed-loop anesthetic delivery system could automatically and precisely control the electroencephalogram state of burst suppression and efficiently maintain a medically in...

A Playbook for Real-Time, Closed-Loop Control

SIFT has been developing an approach to adaptable automation control of multiple Unmanned Air Vehicles (UAVs) we call a Playbook because it is based on the metaphor of a sports team’s book of acceptable plays. Playbook represents a “delegation” approach to human-automation interactions because it allows a human operator to task or delegate authority to automation with much of the same flexibili...

Time Optimal Closed - Loop Fuzzy - Control Strategy for Nonlinear Lunar Lander Mission

Real-Time Computation of Closed-Loop Controls

The paper reports on recent progress in the real-time computation of constrained closed-loop optimal control, in particular the special case of nonlinear model predictive control, of large DAE systems arising e.g. from semi-discretization of instationary PDE. Through a combination of, among others, a direct multiple shooting approach, a constrained Gauss-Newton method and an operation point emb...